NINDS is the nation’s primary supporter of biomedical research on the brain and the nervous system. NICHD sponsors research on development, before and after birth, maternal, .nd Health, reproductive biology and population issues; and medical rehabilitation. For further information about Rett syndrome, visit here.
With this goal, she and her team analyzed gene activity patterns in the brains of mice with a MECP2 deficiency and in mice with a MECP2 duplication . In other experiments, showed only minor differences between the brains of normal and MECP2 – mutant mice, but these studies measured gene activity in the brain. Zoghbi, the group focuses on a brain region in the hypothalamus, one of which is known to produce hormones that influence growth, mood, and the sleep-wake cycle – to all usually derailed in Rett syndrome. Continue reading