The primary purpose of this study is to show an adaptive method of dosing AKB-6548 that will enable subjects to properly raise their hemoglobin levels from baseline without extreme excursions to higher than 13.0 g/dL. An interview with Professor Lesley JonesDeaths from avoidable risk elements: an interview with Dr Ali Mokdad, IHME Anemia associated with CKD remains a serious and under-treated public health risk, associated with higher prices of mortality and morbidity, said Robert Shalwitz, Chief Medical Officer of Akebia.A complete of 162 patients received the entire treatment routine of five cycles of chemoradiotherapy, and 164 received the full dosage of radiotherapy. Two patients received a higher dose of radiotherapy . The most typical reason for not really completing all chemotherapy cycles was a low platelet count. One individual died while awaiting medical procedures after chemoradiotherapy, probably owing to a perforation of the esophagus, accompanied by major hemorrhage in the lack of thrombocytopenia. All other major nonhematologic toxic effects of grade 3 or more occurred in under 13 percent of sufferers in this group.