APC-300 significantly inhibits the development of prostate malignancy cells.

This year 2010, the American Malignancy Society reported that 217,730 men in the U.S. Were identified as having prostate cancer and 32,050 had been projected to die from the disease. While treatment with medical procedures and/or radiation is prosperous often, about one-third of sufferers will encounter disease recurrence. Regardless of the initial achievement of androgen deprivation therapy , prostate cancers continues to progress from androgen-dependent prostate cancers to castrate-resistant prostate cancers in most of the patients within a matter of years.But investigators found that elephant cells carry 40 copies. Bloodstream drawn from eight African and Asian elephants was then stacked up against blood drawn from 11 healthy people and 10 individuals who had Li-Fraumeni Syndrome. That is a genetic condition in which patients have only a single duplicate of P53, resulting in a 90 % life time risk for developing cancer. All of the samples were exposed to radiation to inflict DNA damage. Initially, it made an appearance that elephant P53 genes and human P53 genes reacted similarly: Both set out to repair DNA flaws. But delving much deeper, the investigators discovered that an elephant’s P53 genes were more likely to play the part of assassin than doctor, killing off a lot more damaged cells than their human counterparts. ‘These genes in fact kill more than doubly many damaged cells as our genes carry out,’ Schiffman said.