When vessels contract, bloodstream and oxygen are diminished, resulting in coronary artery disease. The biology behind this course of events, referred to as vasodilation, happens through nitric oxide, a gaseous molecule synthesized by an enzyme known as eNOS, which relaxes the vascular smooth muscle tissue cells lining the external level of coronary vessels. If, in this course of events, nitric oxide encounters another band of molecules known as reactive oxygen species , then NO is inactivated, and of dilating instead, blood vessels contract.If, after 2 weeks, the platelet count hadn’t increased by 20,000 per cubic millimeter from platelet-transfusion or baseline requirements had not decreased, the dosage was increased by 25 mg every 2 weeks to a maximum of 150 mg. Patients received transfusions as supportive treatment to maintain platelets at a rate above 10, 000 cells per cubic millimeter and hemoglobin at a known level above 10 g per deciliter. Bone marrow morphologic features had been monitored and metaphase cytogenetic evaluation was performed at access and at three months in all patients and then every six months in patients who had a response .