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CML and Ph+ ALL patients treated with TKIs can develop intolerance or resistance as time passes to these therapies. Iclusig is a targeted tumor medicine developed and discovered at ARIAD. It was designed by ARIAD researchers using ARIAD's system of computational chemistry and structure-based drug style to inhibit BCR-ABL, including drug-resistant mutants that occur during treatment. Iclusig may be the only TKI that has received an authorization in Europe for an indication which includes CML and Ph+ ALL individuals with the T315I mutation. ‘For European patients with CML and Philadelphia-positive ALL who’ve been failed by prior therapy, the accelerated authorization of Iclusig is quite positive underscores and information the necessity for new medicines,’ stated Sandy Craine, director of The CML Support Group in britain.