D.D., Ph online rx .D., Anders Kvist, Ph.D., Per-Erik Isberg, M.Sc., Salma Nowroozalizadeh, Ph.D., Antonio J. Biague, M.D., Zacarias J. Da Silva, M.D., Ph.D., Marianne Jansson, Ph.D.D., Ph.D., Hans Norrgren, M.D., Ph.D., and Patrik Medstrand, Ph.D.: Inhibition of HIV-1 Disease Progression by Contemporaneous HIV-2 Infection More than 60 million people have been infected with the human immunodeficiency virus , and despite tremendous initiatives, there is no treatment or effective vaccine against the virus. The organic course of HIV infection is normally described in three stages. The acute infection stage is characterized by viremia, a rapid decrease in CD4+ T-cell count, and development of influenza-like symptoms. In the asymptomatic stage, a continuing and moderate decline in T-cell counts is seen.
The algorithm presented in this analysis, that may discern a notable difference by one factor of 120 in the chance of PML across the patient subgroups, allows for better characterization of risk than that observed with previous methods7 and should assist clinicians to make more informed, individualized treatment decisions.19,20 Other things to consider in determining whether natalizumab is an appropriate treatment are the severity of the multiple sclerosis in the individual, the patient’s prior experience with disease-modifying medications , the security and efficacy of option therapies, and the manner in which risks are conveyed to the individual. Ultimately, the decisions regarding the initiation and length of natalizumab therapy ought to be predicated on a discussion between the physician and the patient with consideration of most factors, like the findings of this analysis.