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For the ASPIRE In-Home Study Group: Threshold-Based Insulin-Pump Interruption for Reduced amount of Hypoglycemia Severe nocturnal hypoglycemia could be catastrophic,1,2 and hypoglycemia remains probably the most formidable barriers to improving glycemic control in patients with diabetes.3 Sensor-augmented insulin-pump therapy offers substantial glycemic benefits, as compared with multiple daily insulin injections, but has not been proven to lower the risk of severe hypoglycemia significantly.4 The automatic suspension of insulin delivery when a preset sensor glucose threshold is reached gets the potential to mitigate hypoglycemia.