Seven of the 10 individuals who required naloxone reported that that they had also used other medicines subsequently, such as cocaine or benzodiazepines, at the time of the overdose. All seven seizures that happened at the clinic had been classified as having some relationship to the study medicine: two occurred in a patient with a brief history of epilepsy and the remaining five occurred in sufferers who had used cocaine or benzodiazepines before the seizure. Discussion In this trial, sufferers assigned to get injectable diacetylmorphine were much more likely to stay in treatment also to reduce their use of illegal drugs and other illegal activities than sufferers assigned to get oral methadone. These findings are consistent with the outcomes of European research that suggest greater efficiency of diacetylmorphine than methadone as maintenance treatment for long-term, treatment-refractory opioid make use of.10,12,13 Two of these trials showed no differences between groups in the rate of retention in treatment for addiction.It has additionally been encouraging to find indicators of ACE-041 activity in a wide range of tumour types, since this aligns with this hypothesis that ACE-041 might have anti-tumour activity in any tumour that has angiogenic activity, regardless of tumour histology. It is also important to note that while we’ve demonstrated significant activity with ACE-041 monotherapy in this study, we would expect to see even more efficacy in upcoming studies with ACE-041 used in combination with various other therapies.’ Prof Sharma and his colleagues are planning further investigations of the safety and tolerability of the medication in an additional group of patients and hope to start phase II studies of ACE-041 in 2011. ‘The anti-VEGF angiogenesis inhibitors, including bevacizumab, sunitinib and sorafenib, have been a significant addition to the armamentarium of anti-tumor therapies,’ stated Prof Sharma.